Description

2H-Cyclopenta[B]Furan-2-Acetonitrile,Hexahydro-,(2-α-,3A-α-,6A-α-)-(9Ci) is a high-purity, advanced pharmaceutical intermediate characterized by its complex, stereochemically defined bicyclic structure. This compound is of significant value for its role as a key chiral building block in the synthesis of complex organic molecules, particularly in medicinal chemistry. It is primarily sought after by research institutions, fine chemical manufacturers, and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the multi-step synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders or possessing complex heterocyclic architectures.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in catalytic asymmetric reactions to introduce specific stereocenters into target molecules with high enantiomeric purity.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to explore new chemical spaces and develop proprietary compound libraries.
• Fine Chemical Production: Used in the custom synthesis of specialty chemicals, agrochemical intermediates, and advanced materials requiring high stereochemical fidelity.
• Process Development & Scale-up: Acts as a reference standard or a key material for developing and optimizing robust, scalable synthetic routes in pilot plants and commercial manufacturing.

Basic Information

Product Name	2H-Cyclopenta[B]Furan-2-Acetonitrile,Hexahydro-,(2-α-,3A-α-,6A-α-)-(9Ci)
CAS No.	127419-57-2
Molecular Formula	C9H13NO
Molecular Weight	151.21 g/mol
Synonyms	Hexahydro-2H-cyclopenta[b]furan-2-acetonitrile, (2α,3aα,6aα)-; (2α,3aα,6aα)-Hexahydro-2H-cyclopenta[b]furan-2-acetonitrile; (2R,3aS,6aS)-Hexahydro-2H-cyclopenta[b]furan-2-acetonitrile; 2H-Cyclopenta[b]furan-2-acetonitrile, hexahydro-, (2α,3aα,6aα)-; 127419-57-2; Cyclopentafuran acetonitrile derivative; Stereoisomeric cyclopenta-fused furan nitrile.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch undergoes comprehensive analytical characterization using techniques such as HPLC, GC, NMR, and chiral analysis to confirm identity, purity, and stereochemical integrity. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring full traceability and compliance with your research or cGMP guidelines for pharmaceutical development. Specifications can be aligned with client-specific requirements for custom synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed to protect the contents from moisture absorption and potential contamination. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.