Description

(E)-4-(2-Fluorophenyl)But-3-Enoic Acid is a high-purity fluorinated organic building block characterized by its α,β-unsaturated carboxylic acid structure with a 2-fluorophenyl substituent. This compound matters as a versatile and critical chiral intermediate in advanced pharmaceutical synthesis, enabling the development of targeted active pharmaceutical ingredients (APIs). It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel drug candidates, particularly in therapeutic areas requiring fluorinated compounds for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the fluorine atom and the acid functionality contribute to biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced organic materials with specific electronic or surface properties.
• Academic & R&D: A valuable reagent for methodological studies in organic chemistry, including cross-coupling reactions and studies on fluorine chemistry.

Basic Information

Product Name	(E)-4-(2-Fluorophenyl)But-3-Enoic Acid
CAS No.	127406-53-5
Molecular Formula	C10H9FO2
Molecular Weight	180.18 g/mol
Synonyms	(E)-4-(2-Fluorophenyl)-3-butenoic acid; trans-4-(2-Fluorophenyl)-3-butenoic acid; 4-(2-Fluorophenyl)but-3-enoic acid; 2-Fluorocinnamic acid, β-methylidene-; (E)-3-(2-Fluorophenyl)propenoic acid, 2-carboxyethylidene derivative; (E)-4-(o-Fluorophenyl)but-3-enoic acid; Fluorophenylbutenoic Acid
EINECS	Contact for details

Quality Control

Our (E)-4-(2-Fluorophenyl)But-3-Enoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP standards where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed in a dry environment. Keep away from strong oxidizers, strong bases, and heat sources.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.