Description

(E)-4-(3-Fluorophenyl)But-3-Enoic Acid is a high-purity fluorinated organic building block with the CAS registry number 127404-67-5. This compound is valued for its role as a key chiral intermediate in the synthesis of complex pharmaceutical molecules and advanced materials. It is primarily sought by research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and production of active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring fluorinated compounds.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the fluorophenyl moiety enhances biological activity and stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in advanced electronic displays and organic light-emitting diodes (OLEDs).
• Academic & Contract Research: Employed in medicinal chemistry and organic synthesis research within universities and contract research organizations (CROs).
• Peptidomimetics & Bioactive Molecules: Useful for incorporating fluorinated phenylalanine analogs into peptides and other bioactive compounds to modulate their properties.
• Custom Synthesis & Scale-up: A starting material for custom synthesis projects, from milligram-scale research to kilogram-scale pilot production.

Basic Information

Product Name	(E)-4-(3-Fluorophenyl)But-3-Enoic Acid
CAS No.	127404-67-5
Molecular Formula	C10H9FO2
Molecular Weight	180.18 g/mol
Synonyms	(E)-3-(3-Fluorophenyl)propenoic acid; trans-3-(3-Fluorophenyl)acrylic acid; (E)-3-(3-Fluorophenyl)acrylic acid; 3-(3-Fluorophenyl)-2-propenoic acid; (E)-3-Fluorocinnamic acid; 3-Fluorocinnamic acid (trans-); β-(3-Fluorophenyl)acrylic acid; (2E)-3-(3-Fluorophenyl)prop-2-enoic acid
EINECS	Contact for details

Quality Control

Our (E)-4-(3-Fluorophenyl)But-3-Enoic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical quality attributes are provided and available upon request. We support compliance with cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.