Description

Iomazenil is a high-purity benzodiazepine receptor ligand with significant research and pharmaceutical applications. This compound is valued for its high affinity and selectivity, making it a critical tool in neurological and psychiatric research. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and diagnostic imaging specialists for the development and study of central nervous system (CNS) agents.

Application

• Pharmaceutical Research & Development: A key intermediate and reference standard in the development of novel anxiolytics, anticonvulsants, and other CNS-targeting therapeutics.
• Neurological Imaging (PET/SPECT): Used as a radioligand precursor (e.g., [123I]Iomazenil) in single-photon emission computed tomography (SPECT) for imaging central benzodiazepine receptors in the brain, aiding in the study of epilepsy, anxiety disorders, and neurodegeneration.
• Biochemical Assays: Employed in in vitro receptor binding studies to characterize GABAA receptor subtypes and screen for new receptor modulators.
• Reference Standard: Serves as an analytical standard in quality control (QC) and method development for pharmacokinetic and metabolic studies.
• Academic Neuroscience Studies: Facilitates fundamental research into the mechanisms of GABAergic neurotransmission, sedation, and memory.

Basic Information

Product Name	Iomazenil
CAS No.	127396-36-5
Molecular Formula	C22H21IN4O3
Molecular Weight	516.33 g/mol
Synonyms	Ro 16-0154; Iomazenil (Ro 16-0154); (S)-N-(2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-3-iodo-1H-pyrazole-5-carboxamide; 3-Iomazenil; (S)-Iomazenil; FG 8205; CCRIS 9389; 1H-1,4-Benzodiazepine-3-carboxamide, N-(2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-3-iodo-1H-pyrazole-5-carboxamide, (S)-
EINECS	Contact for details

Quality Control

Our Iomazenil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and development grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.