Description

3'-(Methylanthraniloyl)-2'-Deoxy-Guanosine Diphosphate is a specialized fluorescent nucleotide analog used as a critical biochemical probe. This compound matters for its ability to act as a non-hydrolyzable GTP analog, specifically inhibiting G-protein signaling pathways in mechanistic studies. Researchers in pharmaceutical discovery, molecular biology, and enzymology require it for investigating nucleotide-binding proteins, signal transduction, and high-throughput screening assays.

Application

• Biochemical Research: As a potent, fluorescently-labeled GTP analog for studying G-protein activation, kinetics, and receptor interactions.
• Enzyme Inhibition Studies: Used to probe the active sites of GTPases and other nucleotide-dependent enzymes due to its non-hydrolyzable diphosphate moiety.
• High-Throughput Screening (HTS): Serves as a key reagent in fluorescence-based assays for drug discovery targeting G-protein-coupled receptors (GPCRs).
• Signal Transduction Research: Essential for elucidating pathways involving small GTPases like Ras, Rho, and Rab families.
• Diagnostic Assay Development: Potential use in developing fluorescent diagnostic kits for detecting specific enzymatic activities.
• Academic & Institutional Research: A fundamental tool for universities and research institutes focused on cell signaling and molecular pharmacology.

Basic Information

Product Name	3'-(Methylanthraniloyl)-2'-Deoxy-Guanosine Diphosphate
CAS No.	127383-33-9
Molecular Formula	C₂₄H₂₇N₆O₁₃P₂
Molecular Weight	669.46 g/mol
Synonyms	Mant-dGDP; 2'-Deoxyguanosine-3'-(N-methylanthraniloyl)-5'-diphosphate; 3'-O-(N-Methylanthraniloyl)-2'-deoxyguanosine-5'-diphosphate; 3'-Mant-2'-deoxy-GDP; Fluorescent GDP analog; Non-hydrolyzable GTP analog; dGTP(Mant) diphosphate; 2'-Deoxy-3'-O-(N-methyl-2-anthraniloyl)guanosine-5'-diphosphate
EINECS	Contact for details

Quality Control

Our 3'-(Methylanthraniloyl)-2'-Deoxy-Guanosine Diphosphate is produced under stringent conditions suitable for sensitive research applications. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and spectroscopic confirmation of structure. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to ensure full traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term stability, store under inert atmosphere or in sealed vials. Allow the product to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
UV-Vis Absorption	Characteristic spectrum
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.