Description

1-(3-Astatobenzyl)Guanidine is a specialized organoastatine compound of significant interest in advanced radiopharmaceutical research. Its unique structure, incorporating the rare astatine-211 isotope, makes it a critical precursor for targeted alpha therapy (TAT) agents. This high-value compound is primarily utilized by research institutions and pharmaceutical developers focused on next-generation oncology treatments and diagnostic radiopharmaceuticals.

Application

• Targeted Alpha Therapy (TAT) Precursor: Serves as a key building block for synthesizing radiopharmaceuticals that deliver alpha radiation directly to cancer cells.
• Oncology Research: Used in the development and evaluation of novel astatine-211 labeled compounds for treating metastatic cancers.
• Radiopharmaceutical Development: Acts as an intermediate in creating diagnostic and therapeutic agents for conditions like thyroid cancer and neuroendocrine tumors.
• Preclinical Studies: Employed in laboratory research to study biodistribution, pharmacokinetics, and therapeutic efficacy of α-emitting conjugates.
• Isotope Labeling Chemistry: Utilized in methodological research for the stable incorporation of astatine into complex organic molecules.
• Molecular Imaging Probes: A precursor for developing highly specific imaging agents for positron emission tomography (PET) or single-photon emission computed tomography (SPECT).

Basic Information

Product Name	1-(3-Astatobenzyl)Guanidine
CAS No.	127367-45-7
Molecular Formula	C8H10AtN3
Molecular Weight	Contact for details
Synonyms	1-[(3-Astatophenyl)methyl]guanidine; 3-(Astatobenzyl)guanidine; N-(3-Astatobenzyl)guanidine; At-211 labeled benzylguanidine derivative; Meta-astatobenzylguanidine (MABG); Therapeutic MIBG analog; Astatine-211 benzylguanidine; [211At]SAG
EINECS	Contact for details

Quality Control

Every batch of 1-(3-Astatobenzyl)Guanidine is produced and controlled under strict radiopharmaceutical-grade conditions to ensure the highest standards of purity and specific activity. Our quality assurance protocol includes rigorous analytical testing for radiochemical purity, radionuclidic purity, and chemical identity. A comprehensive Certificate of Analysis (COA) detailing batch-specific results, including HPLC chromatograms and gamma spectroscopy data, is provided with each shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Due to its strictly light-sensitive and hygroscopic nature, this material must be stored in a dedicated, shielded environment at controlled room temperature (15-25°C) or as specified on the label. Protect from moisture and store according to all applicable radiation safety regulations.

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow solution
Identification (HPLC)	Conforms to reference standard
Radiochemical Purity (HPLC)	≥ 95%
Radionuclidic Purity (Gamma Spectroscopy)	≥ 99.9% Astatine-211
Specific Activity	Contact for details
pH	4.0 - 7.0
Sterility (for injectable grade)	Sterile
Endotoxin (for injectable grade)	< 17.5 EU/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.