Description

4-Fluoro-3-(trifluoromethyl)anisole is a high-purity fluorinated aromatic ether building block of significant interest in advanced chemical synthesis. This compound matters for its unique trifluoromethyl and fluoro substituents, which are critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. It is primarily needed by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in candidates targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for high-performance displays (LCDs) due to its influence on dielectric anisotropy and viscosity.
• Organic Electronics: Employed in the development of novel organic semiconductors and electro-optic materials where electron-withdrawing groups are required.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Chemical Research: A versatile building block in medicinal and synthetic chemistry for exploring structure-activity relationships (SAR) and novel molecular architectures.

Basic Information

Product Name	4-Fluoro-3-(trifluoromethyl)anisole
CAS No.	127271-65-2
Molecular Formula	C8H6F4O
Molecular Weight	194.13 g/mol
Synonyms	1-Fluoro-2-methoxy-4-(trifluoromethyl)benzene; 4-Fluoro-3-(trifluoromethyl)phenyl methyl ether; 3-Trifluoromethyl-4-fluoroanisole; Benzene, 1-fluoro-2-methoxy-4-(trifluoromethyl)-; 2-Methoxy-4-(trifluoromethyl)fluorobenzene; 4-Fluoro-α,α,α-trifluoro-m-anisole; m-Anisole, 4-fluoro-3-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-(trifluoromethyl)anisole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability and consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and organic solvents. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Purity (HPLC)	≥ 97.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.