Description

(E)-4-(Dimethylamino)-1,1,1-Trifluorobut-3-En-2-One CAS NO 127223-93-2 is a high-value, fluorinated organic building block characterized by its unique α,β-unsaturated ketone structure with a dimethylamino and trifluoromethyl group. This compound is essential for introducing the trifluoromethyl moiety into complex molecules, a key modification in modern pharmaceutical and agrochemical research that enhances metabolic stability, lipophilicity, and bioavailability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for synthesizing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and oncology, where the CF₃ group is a critical pharmacophore.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group to improve weatherfastness and biological activity.
• Material Science Research: Serves as a precursor for fluorinated polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing properties and potential for cross-coupling reactions.
• Chemical Biology Probes: Employed in the development of fluorinated tags and probes for studying biological mechanisms and enzyme interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences industry.

Basic Information

Item	Detail
Product Name	(E)-4-(Dimethylamino)-1,1,1-Trifluorobut-3-En-2-One
CAS No.	127223-93-2
Molecular Formula	C₆H₈F₃NO
Molecular Weight	167.13 g/mol
Synonyms	4-(Dimethylamino)-1,1,1-trifluoro-3-buten-2-one; 1,1,1-Trifluoro-4-(dimethylamino)-3-buten-2-one; (E)-4-(N,N-Dimethylamino)-1,1,1-trifluorobut-3-en-2-one; 4-(Dimethylamino)-1,1,1-trifluorobut-3-en-2-one; (E)-4-(Dimethylamino)-1,1,1-trifluoro-3-buten-2-one; DMATFB; Trifluoromethyl enaminone building block
EINECS	Contact for details

Quality Control

Our production of (E)-4-(Dimethylamino)-1,1,1-Trifluorobut-3-En-2-One adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for research and scale-up applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality systems are designed to support cGMP compliance for advanced intermediates, ensuring traceability and documentation for regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive and should be handled under an inert atmosphere for prolonged storage to maintain stability. Keep away from strong acids/bases and oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.