Description

(1S,2S)-2-Fluorocyclopropanecarboxylic Acid CAS NO 127199-14-8 is a high-value, chiral fluorinated building block essential for modern synthetic chemistry. Its unique strained cyclopropane ring and stereodefined fluorine atom make it a critical intermediate for introducing conformational rigidity and modulating electronic properties in target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Agrochemical Research: Used in the synthesis of advanced herbicides and pesticides with improved efficacy and environmental profiles.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science: A building block for specialty polymers and advanced materials where fluorination enhances stability and performance.
• Medicinal Chemistry SAR Studies: Employed to explore structure-activity relationships by introducing the cyclopropane scaffold and fluorine atom into lead compounds.
• Fluorine Chemistry Research: A valuable substrate for studying stereoselective fluorination reactions and the properties of fluorinated carbocycles.

Basic Information

Product Name	(1S,2S)-2-Fluorocyclopropanecarboxylic Acid
CAS No.	127199-14-8
Molecular Formula	C4H5FO2
Molecular Weight	104.08 g/mol
Synonyms	(1S,2S)-2-Fluorocyclopropane-1-carboxylic Acid; trans-2-Fluorocyclopropanecarboxylic Acid; (1S,2S)-rel-2-Fluorocyclopropanecarboxylic Acid; Fluorocyclopropanecarboxylic Acid; 2-Fluorocyclopropanecarboxylic Acid, (1S,2S)-; Cyclopropanecarboxylic acid, 2-fluoro-, (1S,2S)-
EINECS	Contact for details

Quality Control

Every batch of (1S,2S)-2-Fluorocyclopropanecarboxylic Acid is produced and tested under a strict quality management system. We ensure high chiral purity and chemical integrity through advanced analytical techniques including chiral HPLC and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with each shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its acidic nature, keep away from incompatible materials such as strong bases and oxidizing agents. For long-term storage, consider keeping the container under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.