Description

cis-2-Fluorocyclopropyl)-n-((R)-1-Phenylethyl)Acetamide is a chiral, fluorinated acetamide derivative featuring a cyclopropyl scaffold, a key structural motif in medicinal chemistry. This compound is valued for its role as a sophisticated synthetic intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought by research and development teams in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecules with potential biological activity.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, particularly in programs targeting central nervous system (CNS) disorders, infectious diseases, and metabolic conditions.
• Agrochemical Research: Used in the discovery and development of new-generation pesticides and herbicides, where the fluorocyclopropyl group can enhance metabolic stability and bioavailability.
• Methodology Development: Serves as a test substrate in academic and industrial research for developing new asymmetric synthesis and fluorination methodologies.
• Ligand and Catalyst Synthesis: Employed in the preparation of chiral ligands or organocatalysts for enantioselective transformations.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes to study enzyme function and biological pathways.

Basic Information

Product Name	cis-2-Fluorocyclopropyl)-n-((R)-1-Phenylethyl)Acetamide
CAS No.	127199-12-6
Molecular Formula	C13H16FNO
Molecular Weight	221.27 g/mol
Synonyms	N-[(1R)-1-Phenylethyl]-2-[(1S,2S)-2-fluorocyclopropyl]acetamide; (R)-N-(1-Phenylethyl)-2-((1S,2S)-2-fluorocyclopropyl)acetamide; 2-((1S,2S)-2-Fluorocyclopropyl)-N-((R)-1-phenylethyl)acetamide; (1S,2S)-2-Fluorocyclopropanecarboxylic acid (R)-α-methylbenzylamide (derivative); Acetamide, N-[(1R)-1-phenylethyl]-2-[(1S,2S)-2-fluorocyclopropyl]-; Fluorocyclopropyl acetamide derivative
EINECS	Contact for details

Quality Control

Our production of cis-2-Fluorocyclopropyl)-n-((R)-1-Phenylethyl)Acetamide adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. Every lot is analyzed using advanced techniques including HPLC, GC, and NMR to confirm identity, chiral purity, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.