Description

n-Desmethyl Clarithromycin (9E)-Oxime is a key pharmaceutical intermediate and impurity standard in the synthesis and quality control of the macrolide antibiotic clarithromycin. Its primary value lies in enabling the precise monitoring and control of the desmethyl impurity profile during API manufacturing, which is critical for ensuring final product purity and regulatory compliance. This compound is essential for pharmaceutical R&D laboratories, quality assurance/quality control (QA/QC) departments, and manufacturers of active pharmaceutical ingredients (APIs) who require high-purity reference standards.

Application

• Primary use as a reference standard and impurity marker in the analytical testing of clarithromycin API and finished dosage forms.
• Critical intermediate in the research, development, and synthesis of clarithromycin and its derivatives.
• Essential component for method development and validation in HPLC, UPLC, and LC-MS assays within pharmaceutical QC laboratories.
• Used in stability studies to track degradation pathways and establish impurity limits for clarithromycin-based products.
• Serves as a starting material or building block in medicinal chemistry research exploring new macrolide structures.

Basic Information

Product Name	n-Desmethyl Clarithromycin (9E)-Oxime
CAS No.	127182-43-8
Molecular Formula	C37H66N2O12
Molecular Weight	730.93 g/mol
Synonyms	6-O-Methylerythromycin 9-(E)-Oxime, N-Desmethyl Clarithromycin Oxime; Clarithromycin Impurity F (EP); Clarithromycin Related Compound F; (9E)-6-O-Methylerythromycin 9-Oxime; 6-O-Methylerythromycin A 9-(E)-Oxime; (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-4-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-14-ethyl-7,12,13-trihydroxy-3,5,7,9,11,13-hexamethyl-6-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]oxacyclotetradecane-2,10-dione 9-oxime
EINECS	Contact for details

Quality Control

Our n-Desmethyl Clarithromycin (9E)-Oxime is produced and tested under a strict quality management system. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency, meeting the requirements for use as a pharmaceutical reference standard. A detailed Certificate of Analysis (COA) providing HPLC purity, spectral confirmation (IR, NMR, MS), and other critical parameters is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.