Description

Connexin 26 CAS NO 127120-53-0 is a synthetic peptide corresponding to a specific sequence of the human Connexin 26 (Cx26) protein, a crucial component of gap junctions. This compound is essential for fundamental biological research focused on intercellular communication, cellular signaling, and the molecular basis of genetic disorders. It is primarily utilized by researchers and scientists in the fields of molecular biology, biochemistry, and pharmacology for applications such as antibody production, assay development, and functional studies of connexin-related diseases.

Application

• Research Reagent: Used as a critical tool in biochemical and cell biology laboratories for studying gap junction structure and function.
• Antigen for Antibody Production: Serves as an immunogen for generating specific polyclonal or monoclonal antibodies against Connexin 26.
• Assay Development: Employed in the development and validation of ELISA, Western blot, and other immunoassay techniques to detect Cx26 expression.
• Functional Studies: Applied in research investigating the role of Connexin 26 mutations in genetic conditions such as nonsyndromic hearing loss and skin disorders.
• Cell Signaling Research: Utilized in experiments exploring the mechanisms of intercellular calcium signaling, metabolite transfer, and electrical coupling.
• Pharmaceutical Target Investigation: Acts as a target molecule in screening assays for potential therapeutic compounds aimed at modulating gap junction activity.

Basic Information

Product Name	Connexin 26
CAS No.	127120-53-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Gap Junction β-2 Protein (GJB2) Peptide; Cx26 Peptide; Connexin-26 Fragment; GJB2 Fragment; Human Connexin 26 Synthetic Peptide; Intercellular Communication Peptide; Gap Junction Channel Forming Peptide
EINECS	Contact for details

Quality Control

Our Connexin 26 peptide is manufactured under strict quality-controlled conditions suitable for research applications. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and Mass Spectrometry (MS) for identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, sequence verification, and analytical data is provided with every shipment to ensure traceability and compliance with your research standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a dry environment before opening to minimize moisture absorption. Aliquot into smaller working quantities to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70%
Solubility	Soluble in water or appropriate aqueous buffers
Sequence Verification	Confirmed

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.