Description

Boc-3,4-Dimethoxy-L-Phenylalanine is a protected derivative of the non-proteinogenic amino acid L-DOPA, featuring tert-butoxycarbonyl (Boc) and methoxy protecting groups. This compound is a critical chiral building block in the synthesis of complex peptides and pharmaceutical intermediates, offering enhanced stability and solubility for solid-phase peptide synthesis (SPPS). It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of peptide-based therapeutics, enzyme inhibitors, and other bioactive molecules. The product is supplied under stringent quality control to ensure batch-to-batch consistency for demanding synthetic applications.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in Solid-Phase Peptide Synthesis (SPPS) and solution-phase synthesis to incorporate modified phenylalanine residues.
• Biochemical Research: Serves as a precursor for enzyme inhibitors, receptor ligands, and other tools in medicinal chemistry research.
• Asymmetric Synthesis: Employed as a building block for constructing complex molecules with defined stereochemistry.
• Protecting Group Chemistry: The Boc group allows for orthogonal deprotection strategies in multi-step organic syntheses.

Basic Information

Product Name	Boc-3,4-Dimethoxy-L-Phenylalanine
CAS No.	127095-97-0
Molecular Formula	C₁₆H₂₃NO₆
Molecular Weight	325.36 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-3,4-dimethoxy-L-phenylalanine; Boc-Dimethoxy-L-Phe-OH; (2S)-2-[(tert-Butoxycarbonyl)amino]-3-(3,4-dimethoxyphenyl)propanoic acid; Boc-L-3,4-Dimethoxyphenylalanine; N-Boc-3,4-Dimethoxy-L-phenylalanine; Fmoc-3,4-Dimethoxy-L-phenylalanine (related compound); BOC-DMOPA
EINECS	Contact for details

Quality Control

Our Boc-3,4-Dimethoxy-L-Phenylalanine is manufactured under a quality management system and undergoes rigorous analytical testing to ensure high purity and consistency. Specifications are designed to meet the needs of pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with each batch to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.