Description

2-Chloro-2.3.3-Trifluorocyclobutanol is a specialized fluorinated cyclobutanol derivative, serving as a high-value synthetic intermediate in advanced chemical manufacturing. Its unique structure, featuring both chlorine and fluorine substituents on a strained cyclobutane ring, makes it a critical precursor for constructing complex molecules with tailored properties. This compound is essential for R&D and production within the pharmaceutical, agrochemical, and advanced materials sectors, where precise fluorination is required to modulate bioactivity, stability, and material characteristics.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those requiring fluorinated motifs to enhance metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the introduction of fluorine atoms improves efficacy and environmental profile.
• Advanced Material Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers, coatings, and liquid crystals with unique thermal and chemical resistance.
• Organic Synthesis Reagent: Employed in academic and industrial research for cycloaddition reactions and as a scaffold for constructing complex, stereodefined cyclic compounds.
• Fluorine Chemistry Research: A valuable compound for studying structure-activity relationships and developing new fluorination methodologies.

Basic Information

Product Name	2-Chloro-2.3.3-Trifluorocyclobutanol
CAS No.	126988-79-2
Molecular Formula	C4H4ClF3O
Molecular Weight	160.52 g/mol
Synonyms	2-Chloro-2,3,3-trifluorocyclobutanol; 2-Chloro-α,α,β-trifluorocyclobutanemethanol; 1-Chloro-2,2,3-trifluorocyclobutanol; Cyclobutanol, 2-chloro-2,3,3-trifluoro-; 126988-79-2; 2-Cl-2,3,3-F3-cyclobutanol
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-2.3.3-Trifluorocyclobutanol is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the precise requirements of your application. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot. Our quality commitment aligns with cGMP principles where applicable, ensuring traceability and consistency for critical industrial and research uses.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Individual Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.