Description

4-Bromobenzenesulphonylacetonitrile is a versatile and high-value organic intermediate characterized by its reactive nitrile and sulfonyl functional groups. This compound is critical for the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors, where it serves as a key building block for active ingredients. It is essential for research chemists and process development scientists in fine chemical manufacturing, enabling the creation of novel sulfonamide derivatives and heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides, leveraging its bromine and sulfonyl groups for bioactivity.
• Material Science Research: Employed in the creation of specialized polymers and liquid crystals where the sulfonylacetonitrile moiety modifies material properties.
• Organic Synthesis Building Block: Utilized in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic substitution reactions due to the reactive bromine atom.
• Chemical Biology Probes: Serves as a starting material for synthesizing activity-based probes and molecular tags for studying biological processes.

Basic Information

Product Name	4-Bromobenzenesulphonylacetonitrile
CAS No.	126891-45-0
Molecular Formula	C8H6BrNO2S
Molecular Weight	260.11 g/mol
Synonyms	p-Bromobenzenesulfonylacetonitrile; (4-Bromophenyl)sulfonylacetonitrile; 4-Bromobenzene-1-sulfonylacetonitrile; Acetonitrile, [(4-bromophenyl)sulfonyl]-; 4-Bromophenylsulfonylacetonitrile; 4-Bromo-benzenesulfonyl-acetonitrile; 4-Bromobenzensulfonylacetonitril
EINECS	Contact for details

Quality Control

Our 4-Bromobenzenesulphonylacetonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.