Description

L-Selectin is a cell adhesion molecule belonging to the selectin family, playing a critical role in the initial stages of leukocyte recruitment and inflammatory response. Its primary function is to mediate the tethering and rolling of leukocytes on vascular endothelial cells, making it a key target for immunological and inflammation research. This high-purity biochemical is essential for researchers and developers in the pharmaceutical and biotechnology sectors, particularly those focused on developing novel anti-inflammatory therapeutics and diagnostic assays. The compound is supplied under stringent quality controls to ensure batch-to-batch consistency for reliable experimental and pre-clinical outcomes.

Application

• Inflammation Research: Used as a key reagent to study leukocyte-endothelial cell interactions, adhesion cascades, and the molecular mechanisms underlying acute and chronic inflammatory diseases.
• Drug Discovery & Development: Serves as a primary target for screening and validating potential inhibitors of selectin-mediated adhesion for therapeutic applications in conditions like arthritis, psoriasis, and ischemia-reperfusion injury.
• Biomarker Studies: Employed in assay development to quantify soluble L-Selectin levels in biological samples, aiding in disease monitoring and prognosis.
• Cell Signaling Pathways: Utilized to investigate downstream signaling events triggered by L-Selectin ligation and its role in immune cell activation.
• Diagnostic Kit Development: Acts as a critical component in the development of ELISA and other immunoassay kits for research and clinical diagnostic purposes.
• Academic & Pre-clinical Research: Provides a reliable tool for universities and research institutes studying immunology, vascular biology, and related fields.

Basic Information

Product Name	L-Selectin
CAS No.	126880-86-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	CD62L Antigen; Leukocyte-Endothelial Cell Adhesion Molecule 1; LECAM-1; Lymph Node Homing Receptor; SELL; Lyam-1; TQ1; Leu-8; DREG; LAM-1; L-Selectin (Human); L-Selectin Protein
EINECS	Contact for details

Quality Control

Our L-Selectin is produced under a quality management system to ensure the highest standards of purity and biological activity. Each batch undergoes rigorous analytical testing, including identity confirmation, purity assessment, and functional activity assays. A comprehensive Certificate of Analysis (COA) detailing purity, concentration, endotoxin levels, and biological activity is provided with every shipment to guarantee traceability and support your regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature before opening to minimize moisture absorption. For extended storage, consider under an inert atmosphere. Aliquot reconstituted solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (SDS-PAGE)	Complies
Purity (SDS-PAGE)	≥ 95%
Assay (Protein Content)	≥ 90% (by UV absorbance)
Biological Activity	Determined by functional binding assay
Endotoxin Level	< 1.0 EU/µg
Solubility	Soluble in water or PBS

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.