Description

5,6-Dimethyl-2-[4-[3-(1-Piperidinomethyl)Phenoxy]-(Z)-2-Butenylamino]-4(1H)-Pyrimidone Dihydrochloride is a high-purity, non-nucleoside reverse transcriptase inhibitor (NNRTI) intermediate of significant pharmaceutical importance. Its value lies in its role as a critical building block for the synthesis of advanced antiviral active pharmaceutical ingredients (APIs), ensuring supply chain reliability for drug manufacturers. This compound is essential for research institutions and pharmaceutical companies engaged in the development and production of next-generation antiviral therapies targeting HIV and other retroviruses.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the manufacture of non-nucleoside reverse transcriptase inhibitor (NNRTI) class antiviral drugs.
• Antiviral API Synthesis: Used in the research, development, and scale-up production of active pharmaceutical ingredients for HIV treatment regimens.
• Biochemical Research: Serves as a reference standard and tool compound in virology and medicinal chemistry research to study viral replication mechanisms.
• Process Chemistry: Employed in process optimization and route scouting for the efficient, GMP-compliant synthesis of complex therapeutic molecules.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials and commercial drug substances.

Basic Information

Product Name	5,6-Dimethyl-2-[4-[3-(1-Piperidinomethyl)Phenoxy]-(Z)-2-Butenylamino]-4(1H)-Pyrimidone Dihydrochloride
CAS No.	126869-04-3
Molecular Formula	C22H31N5O2 • 2HCl
Molecular Weight	486.43 g/mol (free base: 397.52 g/mol)
Synonyms	5,6-Dimethyl-2-((Z)-4-(3-(piperidin-1-ylmethyl)phenoxy)but-2-en-1-ylamino)pyrimidin-4(1H)-one dihydrochloride; NNRTI Intermediate; L-697,661 Intermediate; L-697661 Dihydrochloride; (Z)-5,6-Dimethyl-2-(4-(3-(piperidin-1-ylmethyl)phenoxy)but-2-en-1-ylamino)pyrimidin-4(3H)-one dihydrochloride; Antiviral Intermediate 126869-04-3; Pyrimidone Dihydrochloride Derivative
EINECS	Contact for details

Quality Control

Our 5,6-Dimethyl-2-[4-[3-(1-Piperidinomethyl)Phenoxy]-(Z)-2-Butenylamino]-4(1H)-Pyrimidone Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure compliance with stringent pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.