Description

Rink Amide Linker is a specialized, high-purity chemical building block essential for solid-phase peptide synthesis (SPPS). Its core value lies in providing a robust and acid-labile anchoring point for peptides, enabling efficient cleavage from the resin under mild acidic conditions. This compound is critically needed by researchers and manufacturers in the pharmaceutical, biotechnology, and peptide synthesis industries for developing novel therapeutic peptides and peptidomimetics.

Application

• Primary linker for the solid-phase synthesis of peptide amides using Fmoc/t-Bu chemistry.
• Critical component in the production of therapeutic peptides and peptide-based drug candidates.
• Used in combinatorial chemistry libraries for high-throughput screening of bioactive compounds.
• Essential for synthesizing C-terminal peptide amides, a common motif in many natural hormones and signaling molecules.
• Facilitates the synthesis of complex, modified peptides for research and diagnostic applications.
• Employed in the development of peptide-conjugates for targeted drug delivery systems.

Basic Information

Product Name	Rink Amide Linker
CAS No.	126828-35-1
Molecular Formula	C20H22N2O5
Molecular Weight	370.40 g/mol
Synonyms	4-[(2,4-Dimethoxyphenyl)(Fmoc-amino)methyl]phenoxyacetic acid; Rink Amide AM Resin Linker; Fmoc-Rink Amide Linker; 4-[(R,S)-α-[9H-Fluoren-9-ylmethoxyformamido]-2,4-dimethoxybenzyl]-phenoxyacetic Acid; Rink Amide SPPS Linker; PAL Linker (for peptide amide linker); Fmoc-ADmb Resin Linker; 2,4-Dimethoxy-4'-(carboxymethoxy)benzhydrylamine, N-Fmoc derivative
EINECS	Contact for details

Quality Control

Our Rink Amide Linker is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically ≥98% (HPLC). Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemical and pharmaceutical intermediate production to support your critical research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and performance.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.