Description

H-Leu-His-Leu-Oh is a synthetic tripeptide composed of the amino acids L-Leucine, L-Histidine, and L-Leucine with a free C-terminal carboxylic acid. This compound serves as a crucial pharmaceutical intermediate and a biochemical research tool for studying peptide structure, function, and metabolism. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions engaged in peptide synthesis and proteomics research.

Application

• Pharmaceutical Intermediate: Used in the synthesis of more complex peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Biochemical Research: Serves as a standard, substrate, or building block in enzymatic studies, metabolic pathway analysis, and proteomics research.
• Peptide Library Synthesis: A key component in combinatorial chemistry for creating diverse peptide libraries used in drug discovery and screening.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation in peptide analysis.
• Nutritional Science Studies: Investigated for its role as a potential bioactive peptide or metabolic marker in nutritional and physiological research.

Basic Information

Product Name	H-Leu-His-Leu-Oh
CAS No.	126828-33-9
Molecular Formula	C19H32N6O5
Molecular Weight	424.50 g/mol
Synonyms	L-Leucyl-L-histidyl-L-leucine; Leu-His-Leu; H-L-Leu-L-His-L-Leu-OH; (S)-2-((S)-2-(2-Amino-4-methylpentanamido)-3-(1H-imidazol-4-yl)propanamido)-4-methylpentanoic acid; Tripeptide L-Leu-L-His-L-Leu; 126828-33-9; L-Leu-His-Leu
EINECS	Contact for details

Quality Control

Our H-Leu-His-Leu-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS and NMR for structural confirmation, and chiral analysis to ensure enantiomeric purity. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all relevant specifications. Our quality commitment aligns with the standards expected for research-grade and GMP starting material applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.