Description

Neutrophil Cytosol Factor 47K CAS NO 126805-82-1 is a specialized biochemical reagent, specifically a protein factor involved in the activation of the NADPH oxidase complex in neutrophils. This compound is critical for research into the molecular mechanisms of the respiratory burst, a key component of the innate immune response. It is primarily utilized by researchers and developers in the fields of immunology, pharmacology, and biochemistry for studying oxidative stress, inflammation, and related signaling pathways.

Application

• Biochemical Research: Fundamental studies on the assembly and activation mechanism of the NADPH oxidase complex.
• Immunology Studies: Investigation of neutrophil function, respiratory burst activity, and host defense mechanisms.
• Drug Discovery & Development: Screening and validation of potential therapeutic agents targeting chronic granulomatous disease (CGD) or inflammatory conditions.
• Diagnostic Development: Used as a reference standard or key component in assay development for evaluating immune cell function.
• Academic Research: Essential reagent for university and institutional labs focusing on cell signaling and reactive oxygen species (ROS) production.
• Pharmaceutical R&D: Supporting research into novel anti-inflammatory or immunomodulatory drugs.

Basic Information

Product Name	Neutrophil Cytosol Factor 47K
CAS No.	126805-82-1
Molecular Formula	Contact for details
Molecular Weight	~47 kDa
Synonyms	NCF-47K; p47-phox; Neutrophil Cytosolic Factor 1; NCF1; p47phox; 47 kDa Neutrophil Oxidase Factor; SH3PXD1A; NADPH Oxidase Activator 1
EINECS	Contact for details

Quality Control

Our Neutrophil Cytosol Factor 47K is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and biological activity. Each lot is subjected to rigorous purity and identity testing. A comprehensive Certificate of Analysis (COA) detailing purity, activity, and storage buffer composition is provided with every shipment to support your research integrity.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below in aliquots to avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Purity (SDS-PAGE)	≥ 90%
Identification (Western Blot)	Complies
Biological Activity	Contact for details
Endotoxin Level	< 1.0 EU/µg
Buffer Composition	Specified in COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.