Description

(tert-Butoxy)Carbonyl (S)-3-Amino-4-(4-Methoxy-Phenyl)-Butyric Acid is a protected amino acid derivative of significant importance in advanced organic synthesis. This compound serves as a crucial chiral building block for the construction of complex molecules, particularly in pharmaceutical research and development. It is primarily utilized by pharmaceutical companies, biotechnology firms, and contract research organizations (CROs) engaged in the synthesis of peptide-based therapeutics and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for peptide and peptidomimetic drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce a protected (S)-3-amino-4-(4-methoxyphenyl)butyric acid residue into peptide chains.
• Protease Inhibitor Development: Serves as a core structural component in the research and development of protease inhibitors due to its amino acid-like structure.
• Chemical Biology & Medicinal Chemistry: Employed in the design and synthesis of chemical probes, libraries for high-throughput screening, and novel drug candidates.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material in stereoselective synthesis to control the configuration of new stereocenters.
• Academic & Industrial Research: A valuable reagent for research laboratories in universities and R&D centers exploring new synthetic methodologies and bioactive molecules.

Basic Information

Product Name	(tert-Butoxy)Carbonyl (S)-3-Amino-4-(4-Methoxy-Phenyl)-Butyric Acid
CAS No.	126800-59-7
Molecular Formula	C16H23NO5
Molecular Weight	309.36 g/mol
Synonyms	Boc-(S)-3-Amino-4-(4-methoxyphenyl)butyric acid; (S)-3-[(tert-Butoxycarbonyl)amino]-4-(4-methoxyphenyl)butanoic acid; N-Boc-L-3-Amino-4-(4-methoxyphenyl)butyric acid; N-Boc-(S)-3-Amino-4-(4-methoxyphenyl)butanoic acid; (S)-3-(Boc-amino)-4-(4-methoxyphenyl)butyric acid; Boc-Ampba-OH; Boc-3-Amino-4-(4-methoxyphenyl)butyric acid (S-isomer)
EINECS	Contact for details

Quality Control

Our production of (tert-Butoxy)Carbonyl (S)-3-Amino-4-(4-Methoxy-Phenyl)-Butyric Acid adheres to stringent quality protocols suitable for pharmaceutical R&D applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets exacting standards. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and specific impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.