Description

2,5-Piperazinedione, 3-(Hydroxymethyl)-, (3R)- (9Ci) is a chiral piperazinedione derivative, a key structural motif and advanced intermediate in organic synthesis. Its value lies in its role as a versatile building block for the development of complex, biologically active molecules, particularly in the pharmaceutical sector. This compound is essential for researchers and manufacturers in medicinal chemistry, process development, and fine chemical synthesis who require high-purity, stereochemically defined intermediates.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), especially in oncology and central nervous system (CNS) drug candidates.
• Peptidomimetic Chemistry: Serves as a constrained scaffold or building block for designing and synthesizing peptidomimetics and protease inhibitors.
• Asymmetric Synthesis: Utilized in stereoselective synthesis routes to construct complex heterocyclic compounds with defined chirality.
• Chemical Biology & Proteomics: Used as a specialty reagent in the study of enzyme mechanisms and protein interactions.
• Fine Chemical Production: Employed in the multi-step synthesis of high-value specialty chemicals and catalysts.
• Academic & Industrial R&D: A valuable compound for exploratory research in synthetic methodology and new molecular entity discovery.

Basic Information

Product Name	2,5-Piperazinedione, 3-(Hydroxymethyl)-, (3R)- (9Ci)
CAS No.	126766-09-4
Molecular Formula	C5H8N2O3
Molecular Weight	144.13 g/mol
Synonyms	(3R)-3-(Hydroxymethyl)piperazine-2,5-dione; (R)-3-(Hydroxymethyl)-2,5-piperazinedione; (R)-3-(Hydroxymethyl)piperazine-2,5-dione; (R)-3-Hydroxymethyl-2,5-diketopiperazine; (R)-HMP; (R)-3-Hydroxymethyl-DKP; (3R)-3-(Hydroxymethyl)-2,5-diketopiperazine; (R)-3-(Hydroxymethyl)-2,5-dioxopiperazine
EINECS	Contact for details

Quality Control

Our 2,5-Piperazinedione, 3-(Hydroxymethyl)-, (3R)- (9Ci) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture uptake and degradation. Recommended long-term storage at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.