Description

5-Hydroxyindapamide is a key pharmaceutical intermediate and metabolite of the antihypertensive drug indapamide. This compound is of significant importance for research and development in the pharmaceutical industry, particularly in the study of drug metabolism and the synthesis of related active pharmaceutical ingredients (APIs). It is primarily needed by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in cardiovascular drug development, quality control, and regulatory compliance work.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of indapamide and its derivatives.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical studies to identify and quantify the metabolite in biological samples.
• Pharmacokinetic Research: Essential for studying the absorption, distribution, metabolism, and excretion (ADME) profile of indapamide.
• Impurity Standard: Serves as a certified reference material (CRM) for monitoring and controlling related substances in indapamide API manufacturing.
• Analytical Method Development: Used to develop and validate HPLC, LC-MS, and other chromatographic methods for drug analysis.
• Regulatory Compliance: Supports regulatory filings (e.g., FDA, EMA) by providing necessary impurity and degradation product data.

Basic Information

Product Name	5-Hydroxyindapamide
CAS No.	126750-70-7
Molecular Formula	C16H16ClN3O3S
Molecular Weight	365.83 g/mol
Synonyms	5-Hydroxyindapamide; 4-Chloro-N-(2-methyl-1-indolinyl)-3-sulfamoyl-5-hydroxybenzamide; Indapamide Hydroxy Metabolite; Indapamide Metabolite; 5-OH-Indapamide; 1-(4-Chloro-3-sulfamoylbenzamido)-2-methyl-2,3-dihydro-1H-indol-5-ol; 5-Hydroxy-1-(4-chloro-3-sulfamoylbenzoyl)-2-methylindoline
EINECS	Contact for details

Quality Control

Our 5-Hydroxyindapamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, identity confirmation by IR and MS, and control of specified impurities. Certificates of Analysis (COA) detailing all test results are provided to ensure compliance with your research and manufacturing standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.