Description

Proto-Oncogene Protein Ski CAS NO 126648-96-2 is a critical regulatory protein involved in cellular signaling pathways, particularly those governing cell growth, differentiation, and transformation. This high-purity biological reagent is essential for advanced research in oncology and developmental biology, enabling scientists to study the mechanisms of tumor suppression and progression. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on cancer therapeutics and molecular diagnostics.

Application

• Biomedical Research: Fundamental studies on TGF-β signaling pathways, cellular differentiation, and oncogene/tumor suppressor interactions.
• Drug Discovery & Target Validation: Used as a key reagent in high-throughput screening assays to identify novel compounds that modulate Ski protein activity for potential cancer therapies.
• Diagnostic Development: Serves as a reference standard or antigen in the development of immunoassays and diagnostic kits for detecting protein expression levels in clinical samples.
• Cell Signaling & Pathway Analysis: Essential for in vitro and in vivo experiments to elucidate the role of Ski in embryogenesis, neural development, and skeletal muscle formation.
• Protein-Protein Interaction Studies: Used in co-immunoprecipitation, pull-down assays, and yeast two-hybrid screens to map interaction partners within transcriptional complexes.
• Recombinant Protein Production: Acts as a reference material for quality control during the production of recombinant Ski protein or related biologics.

Basic Information

Product Name	Proto-Oncogene Protein Ski
CAS No.	126648-96-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Ski Oncogene; SKI Proto-Oncogene; V-Ski Avian Sarcoma Viral Oncogene Homolog; Sloan-Kettering Institute Proto-Oncogene; c-Ski; SKI Nuclear Oncogene; Ski Protein; Transforming Protein Ski; SKI Human.
EINECS	Contact for details

Quality Control

Our Proto-Oncogene Protein Ski is produced and handled under stringent quality management systems. Each batch undergoes rigorous analytical testing, including purity assessment by HPLC and identity confirmation via mass spectrometry and immunoblotting, to ensure it meets the exacting standards required for critical research applications. A comprehensive Certificate of Analysis (COA) detailing purity, biological activity (where applicable), and endotoxin levels is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or solution
Identification (Mass Spec)	Conforms
Purity (SDS-PAGE)	> 90%
Purity (HPLC)	> 95%
Endotoxin Level	< 1.0 EU/µg
Biological Activity	Assay-dependent; refer to COA
Solubility	Soluble in appropriate aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.