Description

D-Serine, n-[(1,1-Dimethylethoxy)Carbonyl]-, Methyl Ester, 4-Methylbenzenesulfonate (Ester) (9Ci) CAS NO 126645-21-4 is a protected serine derivative, specifically a Boc-protected D-serine methyl ester tosylate salt, serving as a crucial chiral building block in advanced organic synthesis. This compound is valued for its role in introducing the D-serine moiety into peptide chains and complex molecules while offering enhanced stability and solubility for precise chemical transformations. It is primarily required by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, peptidomimetics, and bioactive compounds where stereochemical integrity is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for neurological and metabolic disorders.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate the D-serine residue, which can confer protease resistance and alter biological activity in synthetic peptides.
• Proteomics & Biochemical Research: Employed as a standard or reagent in studying enzyme mechanisms, substrate specificity, and protein-protein interactions.
• Asymmetric Synthesis: Serves as a starting material or intermediate for the asymmetric synthesis of more complex, non-natural amino acids and other chiral molecules.
• Glycopeptide & Glycomimetic Synthesis: Useful in the preparation of glycopeptide analogs and other carbohydrate-mimetic compounds for drug discovery.

Basic Information

Product Name	D-Serine, n-[(1,1-Dimethylethoxy)Carbonyl]-, Methyl Ester, 4-Methylbenzenesulfonate (Ester) (9Ci)
CAS No.	126645-21-4
Molecular Formula	C16H25NO7S
Molecular Weight	375.44 g/mol
Synonyms	Boc-D-serine methyl ester tosylate; (R)-2-((tert-Butoxycarbonyl)amino)-3-hydroxypropanoic acid methyl ester 4-methylbenzenesulfonate; Methyl (R)-2-((tert-butoxycarbonyl)amino)-3-hydroxypropanoate 4-methylbenzenesulfonate; Boc-D-Ser-OMe.TosOH; N-Boc-D-serine methyl ester p-toluenesulfonate; D-Serine, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester, 4-methylbenzenesulfonate; tert-Butoxycarbonyl-D-serine methyl ester tosylate salt
EINECS	Contact for details

Quality Control

Our D-Serine, n-[(1,1-Dimethylethoxy)Carbonyl]-, Methyl Ester, 4-Methylbenzenesulfonate (Ester) (9Ci) is produced under a strict quality management system to ensure batch-to-batch consistency and high purity suitable for research and development applications. All products undergo rigorous analytical testing, including chiral purity verification, to meet exacting standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.