Description

Intercellular Adhesion Molecule-1 (ICAM-1) is a critical cell surface glycoprotein that plays a fundamental role in mediating leukocyte adhesion and transmigration during inflammatory and immune responses. Its importance lies in its function as a key signaling molecule and adhesion receptor, making it an essential research tool and a significant therapeutic target. This high-purity biochemical is primarily needed by researchers and developers in the fields of immunology, oncology, and inflammatory disease research, as well as by pharmaceutical companies engaged in drug discovery and diagnostic assay development.

Application

• Biomedical Research: Used as a standard or reagent in studies investigating leukocyte-endothelial cell interactions, inflammation pathways, and immune system regulation.
• Drug Discovery & Development: Serves as a target protein for screening and validating potential therapeutic compounds, particularly for anti-inflammatory and immunomodulatory drugs.
• Diagnostic Assay Development: Employed in the development of ELISA kits, flow cytometry assays, and other in vitro diagnostic (IVD) tools to quantify soluble ICAM-1 levels in biological samples.
• Cell Signaling Studies: Essential for research focused on intracellular signaling cascades triggered by ICAM-1 binding and its role in disease progression.
• Academic & Institutional Research: A key reagent for universities and research institutes studying cardiovascular diseases, autoimmune disorders, and cancer metastasis.
• Biopharmaceutical Production: May be used in process development and quality control for biologics targeting adhesion molecules.

Basic Information

Product Name	Intercellular Adhesion Molecule-1
CAS No.	126547-89-5
Molecular Formula	Data on Request
Molecular Weight	Data on Request
Synonyms	ICAM-1; CD54 Antigen; Intercellular Adhesion Molecule 1; Major Group Rhinovirus Receptor; BB2; CD54; Human Rhinovirus Receptor; ICAM1
EINECS	Contact for details

Quality Control

Our Intercellular Adhesion Molecule-1 is produced and handled under stringent quality management protocols to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including purity assessment by HPLC and identity confirmation. A detailed Certificate of Analysis (COA) documenting all specifications and test results is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For prolonged storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Biological Activity	Assessed by functional binding assay
Endotoxin Level	< 1.0 EU/mg
Moisture Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.