Description

16-Hydroxyisotretinoin is a significant metabolite and derivative of isotretinoin, a compound of major importance in dermatological research and pharmaceutical development. This high-purity intermediate is critical for the synthesis of novel retinoid analogs and for conducting detailed metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of active pharmaceutical ingredients (APIs) focused on dermatology and oncology.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of advanced retinoid-based therapeutics.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical studies to understand the pharmacokinetics and metabolism of isotretinoin.
• Research & Development: Essential for academic and industrial research into retinoid receptor activity, mechanism of action, and structure-activity relationships (SAR).
• Dermatological Drug Development: Employed in the development of new treatments for severe acne, psoriasis, and other keratinization disorders.
• Oncology Research: Investigated for potential applications in cancer research due to the role of retinoids in cell differentiation and apoptosis.
• Quality Control: Serves as a certified reference material (CRM) for the purity and potency testing of isotretinoin-based pharmaceutical products.

Basic Information

Product Name	16-Hydroxyisotretinoin
CAS No.	126532-33-0
Molecular Formula	C20H28O3
Molecular Weight	316.44 g/mol
Synonyms	16-Hydroxy-13-cis-retinoic Acid; (2Z,4E,6E,8E)-3-Methyl-9-(2,6,6-trimethyl-1-hydroxycyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic Acid; Isotretinoin Metabolite; 13-cis-16-Hydroxyretinoic Acid; Ro 22-6595
EINECS	Contact for details

Quality Control

Our 16-Hydroxyisotretinoin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent high quality.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.