Description

1-(2,2,2-Trifluoroacetyl)-4-Piperidinecarboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a reactive trifluoroacetyl group on a piperidine scaffold. This compound is critical for medicinal chemists in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disease targets. It is primarily utilized by R&D and process development teams in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce fluorine-containing motifs to enhance drug-like properties.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing complex molecules in drug discovery and development pipelines.
• API Synthesis: Used in the production of Active Pharmaceutical Ingredients (APIs), especially those targeting neurological and psychiatric disorders.
• Fluorinated Compound Research: Serves as a versatile precursor for introducing the trifluoroacetyl group, a valuable moiety for modulating lipophilicity, metabolic stability, and bioavailability in lead optimization.
• Agrochemical Development: Employed in the research and synthesis of novel herbicides and pesticides where fluorine substitution is beneficial.
• Chemical Biology Probes: Useful in the design and synthesis of chemical probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical raw material for CDMOs (Contract Development and Manufacturing Organizations) offering bespoke synthesis services.

Basic Information

Product Name	1-(2,2,2-Trifluoroacetyl)-4-Piperidinecarboxylic Acid
CAS No.	126501-70-0
Molecular Formula	C8H8F3NO3
Molecular Weight	223.15 g/mol
Synonyms	4-Piperidinecarboxylic acid, 1-(2,2,2-trifluoroacetyl)-; 1-Trifluoroacetylisonipecotic Acid; 1-(Trifluoroacetyl)piperidine-4-carboxylic acid; Isonipecotic acid, N-trifluoroacetyl-; N-Trifluoroacetyl-4-piperidinecarboxylic acid; 4-Carboxy-1-(trifluoroacetyl)piperidine; 1-(Trifluoroacetyl)isonipecotic Acid; 1-(2,2,2-Trifluoroacetyl)piperidine-4-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1-(2,2,2-Trifluoroacetyl)-4-Piperidinecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.