Description

Keratinocyte Growth Factor is a potent, naturally occurring protein that plays a critical role in epithelial cell proliferation, differentiation, and wound healing. This high-purity recombinant protein is essential for advanced biomedical research and therapeutic development, offering precise biological activity. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on dermatology, regenerative medicine, and oncology.

Application

• Cell Culture & Tissue Engineering: Used as a key growth supplement to promote the proliferation and maintenance of keratinocytes and other epithelial cell lines in vitro.
• Wound Healing Research: Investigated in preclinical studies for its potential to accelerate re-epithelialization and tissue repair in models of burns, ulcers, and surgical wounds.
• Dermatological Product Development: Serves as an active ingredient in R&D for topical formulations aimed at skin regeneration, anti-aging, and treating conditions like epidermolysis bullosa.
• Oncology & Radioprotection Studies: Explored for its cytoprotective effects on epithelial tissues, potentially mitigating mucosal damage caused by chemotherapy or radiation therapy.
• Biopharmaceutical Manufacturing: Employed in process development for cell-based therapies and as a critical reagent in quality control assays for products targeting epithelial tissues.
• Basic Biomedical Research: A fundamental tool for studying signal transduction pathways, cell cycle regulation, and the molecular mechanisms of epithelial biology.

Basic Information

Product Name	Keratinocyte Growth Factor
CAS No.	126469-10-1
Molecular Formula	C816H1321N233O255S9
Molecular Weight	Approx. 19.2 kDa
Synonyms	KGF; Palifermin; Recombinant Human Keratinocyte Growth Factor (rhKGF); FGF-7; Fibroblast Growth Factor-7; Heparin-binding growth factor 7; HBGF-7
EINECS	Contact for details

Quality Control

Our Keratinocyte Growth Factor is manufactured under stringent conditions to ensure the highest standards of purity and biological activity. Each batch is subjected to a comprehensive battery of analytical tests, including SDS-PAGE, HPLC for purity, endotoxin testing (LAL), and rigorous bioactivity assays to confirm specific potency. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -70°C to -80°C to prevent repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the vial is at room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (SDS-PAGE)	Single band, ~19-22 kDa
Purity (HPLC)	≥ 95%
Endotoxin (LAL)	< 1.0 EU/µg
Biological Activity (Cell Proliferation Assay)	ED50 ≤ 2.0 ng/mL
Protein Content (UV Absorption)	Contact for details
Solubility	Soluble in sterile PBS or cell culture medium

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.