Description

Perforin CAS NO 126465-35-8 is a pore-forming cytolytic protein that plays a critical role in the immune system's cytotoxic response. This protein is essential for inducing apoptosis in target cells, making it a vital research tool for immunology and cell biology studies. It is primarily utilized by researchers and developers in the fields of biomedical research, pharmaceutical development, and diagnostic assay production to investigate immune-mediated cell death pathways and develop novel therapeutic strategies.

Application

• Immunological Research: Fundamental studies on cytotoxic T lymphocyte (CTL) and natural killer (NK) cell function.
• Cancer Research: Investigation of immune evasion mechanisms and development of immunotherapies.
• Autoimmune Disease Studies: Research into conditions where perforin-mediated cytotoxicity is dysregulated.
• Virology: Studying host immune responses to viral infections.
• Biomarker Development: Potential use in diagnostic assays for immune disorders.
• Drug Discovery: Screening for compounds that modulate the perforin/granzyme pathway.
• Reagent Production: Used as a key component in specialized research kits and assays.
• Cell Signaling Pathways: Elucidation of apoptosis and necroptosis mechanisms.

Basic Information

Product Name	Perforin
CAS No.	126465-35-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Cytolysin; Pore-forming protein (PFP); Perforin-1; PRF1; P1; HPLH2; Cytolytic protein; Lymphocyte pore-forming protein; Membrane attack complex/perforin (MACPF) domain-containing protein
EINECS	Contact for details

Quality Control

Our Perforin is produced and handled under stringent quality management systems to ensure batch-to-batch consistency and biological activity. Each lot undergoes comprehensive analytical characterization, including purity assessment and functional activity testing. Certificates of Analysis (COA) detailing specific purity, concentration, and bioactivity are provided with every shipment to support your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. This product is hygroscopic (moisture-sensitive). Avoid repeated freeze-thaw cycles. Aliquot into working volumes upon receipt to maintain optimal activity.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or solution
Identification (SDS-PAGE/Western Blot)	Conforms
Purity (SDS-PAGE)	≥ 90%
Protein Concentration	As per COA
Biological Activity (Cytotoxicity Assay)	As per COA
Endotoxin Level (LAL Test)	< 1.0 EU/µg
Solubility	Reconstitutes in appropriate buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.