Description

Lissoclinamide 8 is a naturally derived cyclic depsipeptide isolated from marine ascidian-associated bacteria, recognized for its potent and selective biological activity. It serves as a high-value molecular probe in oncology and neuropharmacology research due to its ability to modulate protein–protein interactions critical in cell signaling pathways. Researchers in academic institutions, biopharmaceutical R&D labs, and contract research organizations (CROs) rely on this compound for target validation, mechanism-of-action studies, and early-stage drug discovery programs. Lissoclinamide 8 CAS NO 126452-98-0 is supplied under stringent quality controls to ensure batch-to-batch reproducibility and structural integrity.

Application

• Target identification and validation in cancer cell line models (e.g., p53-MDM2 pathway inhibition)
• Chemical biology tool for studying apoptosis regulation and mitochondrial membrane permeabilization
• Lead compound optimization in medicinal chemistry campaigns targeting intracellular protein interfaces
• Reference standard for LC-MS/MS method development and bioanalytical assay calibration
• In vitro pharmacodynamic profiling in primary human tumor explant cultures
• Co-crystallization ligand for X-ray structural analysis of target protein complexes
• Positive control in high-content screening (HCS) assays assessing cytoskeletal reorganization
• Stability-indicating reference material for forced degradation studies under ICH Q1 guidelines

Basic Information

Product Name	Lissoclinamide 8
CAS No.	126452-98-0
Molecular Formula	C57H82N12O15
Molecular Weight	1203.35 g/mol
Synonyms	Lissoclinamide-VIII; Lissoclinamide 8; Lissoclinamide VIII; LS-8; NSC 672265; Compound 8 from Lissoclinum patella; Cyclo-(D-Val-L-Leu-D-allo-Ile-Gly-L-Leu-D-Val-L-Leu-D-Val-L-Leu-D-Val); Depsipeptide 8
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch of Lissoclinamide 8 is verified for identity, purity, and structural fidelity using orthogonal analytical methods including HPLC, HRMS, and 1H-NMR. Certificates of Analysis (COA) are available upon request and include full chromatographic traces, spectral data, and residual solvent assessment per ICH Q3C guidelines. The compound is manufactured and tested in accordance with ISO 9001-certified processes and supports GMP-aligned research environments.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8 °C under inert atmosphere (argon or nitrogen) to prevent oxidation and moisture uptake. Due to its hygroscopic nature, minimize exposure to ambient humidity during handling. Maintain desiccated conditions (<30% RH) during long-term storage.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HRMS)	Matches calculated [M+H]+ m/z 1204.6221 ± 0.005
Identification (HPLC)	Retention time matches reference standard (±0.2 min)
Assay (HPLC-UV)	≥95.0%
Related Substances (HPLC)	Single impurity ≤0.5%; Total impurities ≤2.0%
Residual Solvents (GC)	MeOH ≤3000 ppm; Acetonitrile ≤410 ppm; DCM ≤600 ppm
Water Content (KF)	≤5.0%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.