Description

[2-Hydroxy-2-(4-Methoxy-Phenyl)-Ethyl]-Carbamic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate of significant importance in modern synthetic chemistry. Its core value lies in its role as a critical building block for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. This compound is essential for research and development chemists, process engineers, and manufacturers in the global pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for scalable production.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel APIs, particularly for central nervous system (CNS) agents and other therapeutic compounds.
• Chiral Synthesis Building Block: Utilized in asymmetric synthesis due to its stereogenic center for constructing enantiomerically pure molecules.
• Agrochemical Research: Serves as an intermediate in the development of new generation pesticides and herbicides.
• Peptidomimetics & Prodrug Development: The carbamate and hydroxyl functionalities make it valuable for designing peptide analogs and prodrug formulations.
• Academic & Industrial R&D: Used in medicinal chemistry research for structure-activity relationship (SAR) studies and lead optimization.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) specializing in bespoke chemical synthesis.

Basic Information

Product Name	[2-Hydroxy-2-(4-Methoxy-Phenyl)-Ethyl]-Carbamic Acid tert-Butyl Ester
CAS No.	126395-30-0
Molecular Formula	C14H21NO4
Molecular Weight	267.32 g/mol
Synonyms	tert-Butyl N-[2-hydroxy-2-(4-methoxyphenyl)ethyl]carbamate; (R/S)-2-[(tert-Butoxycarbonyl)amino]-1-(4-methoxyphenyl)ethanol; Boc-4-Methoxy-D,L-phenylglycinol; N-Boc-2-Amino-1-(4-methoxyphenyl)ethanol; 1-(4-Methoxyphenyl)-2-[(tert-butoxycarbonyl)amino]ethanol; 2-[(tert-Butoxycarbonyl)amino]-2-(4-methoxyphenyl)ethanol; N-(tert-Butoxycarbonyl)-4-methoxyphenylglycinol
EINECS	Contact for details

Quality Control

Our [2-Hydroxy-2-(4-Methoxy-Phenyl)-Ethyl]-Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical development. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our commitment to quality supports compliance with cGMP, ICH Q7 guidelines, and relevant global regulatory frameworks for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation. Keep away from heat, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (or as specified)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.