Description

Gastrin Releasing Peptide (18-27), Phe(25)- is a synthetic decapeptide fragment of the gastrin-releasing peptide (GRP), a mammalian bombesin analog. This high-purity peptide is a critical research tool for studying the role of GRP in cellular signaling, neurobiology, and oncology. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and diagnostic developers in the life sciences sector for biochemical and pharmacological investigations.

Application

• Biochemical Research: Used as a specific ligand to study GRP receptor (GRPR) binding, activation, and downstream signaling pathways in vitro.
• Neuroscience Studies: Investigation of the neuromodulatory functions of bombesin-like peptides in the central and peripheral nervous systems.
• Oncology Research: Exploration of GRP/GRPR axis in cancer cell proliferation, with applications in understanding tumor biology for certain carcinomas.
• Pharmacology Assays: Serves as a reference standard or active agent in high-throughput screening (HTS) and drug discovery programs targeting the GRPR.
• Diagnostic Development: Potential use in the development of assays and imaging probes targeting GRPR-expressing tissues.

Basic Information

Product Name	Gastrin Releasing Peptide (18-27), Phe(25)-
CAS No.	126370-72-7
Molecular Formula	C58H84N16O15S
Molecular Weight	1269.5 g/mol
Synonyms	GRP (18-27), Phe(25)-; [Phe25]-GRP (18-27); Gastrin-Releasing Peptide Fragment 18-27 (Phe25); H-Val-Pro-Pro-His-Trp-Ala-Val-Gly-His-Phe-NH2; Bombesin (6-14), Phe(13)-; Neuromedin C (6-14), Phe(13)-; VPPHAWGHP-NH2 (Phe25 variant)
EINECS	Contact for details

Quality Control

Our Gastrin Releasing Peptide (18-27), Phe(25)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and mass spectrometry (MS) for identity confirmation, to ensure compliance with research-grade specifications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Composition	± 10% of theoretical
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.