Description

L-Proline, 4,4-Difluoro-, Methyl Ester (9Ci) is a high-value, fluorinated proline derivative, a key building block in advanced organic synthesis. This compound is engineered to introduce conformational rigidity and enhance metabolic stability in target molecules, making it a critical intermediate for research and development. It is primarily sought after by pharmaceutical and agrochemical R&D teams for the synthesis of novel peptides, enzyme inhibitors, and bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel drug candidates, particularly protease inhibitors and other bioactive peptides.
• Agrochemical Research: Used in the synthesis of advanced, fluorinated active ingredients to improve efficacy and environmental stability.
• Peptide Chemistry: Incorporation into custom peptides to study structure-activity relationships (SAR) and enhance peptide stability against enzymatic degradation.
• Chemical Biology Probes: Serves as a building block for fluorinated amino acid analogs used in probing enzyme mechanisms and protein interactions.
• Material Science: Potential monomer or intermediate for specialized polymers and advanced materials requiring fluorinated components.

Basic Information

Product Name	L-Proline, 4,4-Difluoro-, Methyl Ester (9Ci)
CAS No.	126111-14-6
Molecular Formula	C7H9F2NO2
Molecular Weight	177.15 g/mol
Synonyms	Methyl (2S)-4,4-difluoropyrrolidine-2-carboxylate; (S)-Methyl 4,4-difluoroproline; 4,4-Difluoro-L-proline methyl ester; L-4,4-Difluoroproline methyl ester; (S)-4,4-Difluoropyrrolidine-2-carboxylic acid methyl ester; 4,4-Difluoroproline methyl ester; Methyl 4,4-difluoro-L-prolinate
EINECS	Contact for details

Quality Control

Our L-Proline, 4,4-Difluoro-, Methyl Ester (9Ci) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling by HPLC, NMR, and MS, to ensure it meets the exacting standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.