Description

Eosinophil-Derived Neurotoxin (EDN) is a potent ribonuclease enzyme and a key mediator of the immune response, primarily secreted by activated eosinophils. This protein plays a critical role in host defense against pathogens, particularly viruses, and is a significant biomarker in the study of eosinophil-associated diseases. It is essential for researchers and developers in the fields of immunology, virology, and pharmaceutical development, providing a vital tool for studying antiviral mechanisms, neuroinflammatory pathways, and developing novel therapeutic and diagnostic agents.

Application

• Biomedical Research: Fundamental studies on eosinophil biology, antiviral immunity, and neuroinflammation.
• Diagnostic Development: As a key antigen or standard for immunoassays measuring eosinophil activation in diseases like asthma, hypereosinophilic syndrome, and parasitic infections.
• Therapeutic Target Investigation: Research into modulating EDN activity for treating viral infections or eosinophil-mediated inflammatory disorders.
• Vaccine Adjuvant Research: Exploration of its immunostimulatory properties in vaccine formulation studies.
• Biochemical Reagent: Used as a substrate or enzyme in studies of RNA degradation and ribonuclease activity.
• Cell Signaling Studies: Investigating its role as an alarmin (damage-associated molecular pattern) and its effects on various immune and neural cells.

Basic Information

Product Name	Eosinophil-Derived Neurotoxin
CAS No.	126098-39-3
Molecular Formula	Contact for details
Molecular Weight	~18-19 kDa (Contact for details)
Synonyms	EDN; Eosinophil-Derived Neurotoxin; RNASE2; RNS2; Eosinophil Cationic Protein-2; ECP-2; Ribonuclease 2; Non-secretory ribonuclease; Human liver ribonuclease; Brain ribonuclease
EINECS	Contact for details

Quality Control

Our Eosinophil-Derived Neurotoxin is produced and tested under stringent conditions to ensure high biological activity and purity suitable for research applications. Each batch is characterized for identity and purity using advanced analytical techniques. A comprehensive Certificate of Analysis (COA) detailing purity, activity, and endotoxin levels is provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (SDS-PAGE)	Single band corresponding to ~18-19 kDa
Purity (HPLC)	≥ 95%
Biological Activity	Confirmed by ribonuclease assay
Endotoxin Level (LAL)	< 1.0 EU/µg
Protein Content (UV)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.