Description

Neurokinin A (4-10), Tyr(5)-Trp(6,8,9)-Arg(10)- is a bioactive peptide fragment derived from the Neurokinin A sequence, specifically designed for research into tachykinin receptor signaling pathways. This compound is a critical tool for scientists investigating the physiological roles of neurokinins in the central and peripheral nervous systems, including pain transmission, neurogenic inflammation, and smooth muscle contraction. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neuroscience, peptide chemistry, and drug discovery.

Application

• Neuroscience Research: Used as a selective ligand and agonist in studies of Neurokinin 2 (NK2) receptor function and signaling mechanisms.
• Pharmacological Assay Development: Serves as a reference standard and active control in high-throughput screening (HTS) assays for identifying novel NK2 receptor antagonists.
• Biochemical Studies: Employed in structure-activity relationship (SAR) studies to understand the key amino acid residues responsible for receptor binding and activation.
• In Vitro & Ex Vivo Models: Applied in tissue bath experiments and cell-based assays to study smooth muscle contractility and inflammatory responses mediated by tachykinins.
• Peptide Synthesis & Conjugation: Acts as a starting material or template for the synthesis of modified peptide analogs, fluorescent probes, or bioconjugates for advanced imaging studies.

Basic Information

Product Name	Neurokinin A (4-10), Tyr(5)-Trp(6,8,9)-Arg(10)-
CAS No.	126050-12-2
Molecular Formula	C58H75N17O10
Molecular Weight	1138.33 g/mol
Synonyms	Tyr-Trp-Trp-Trp-Arg; Neurokinin A (4-10) fragment; [Tyr5, Trp6,8,9]-Neurokinin A (4-10); NKA(4-10), [Tyr5, Trp6,8,9]; H-Tyr-Trp-Trp-Trp-Arg-OH; Tachykinin peptide fragment; NK2 receptor agonist peptide
EINECS	Contact for details

Quality Control

Our Neurokinin A (4-10), Tyr(5)-Trp(6,8,9)-Arg(10)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and mass spectrometry (MS) for identity confirmation, to ensure compliance with research-grade specifications. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, dimethyl sulfoxide (DMSO)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.