Description

β-Dendrotoxin CAS NO 126039-38-1 is a potent and highly selective polypeptide neurotoxin derived from the venom of the Eastern Green Mamba (*Dendroaspis angusticeps*). This compound is a critical research tool for the study of voltage-gated potassium (Kv) channels, particularly the Kv1.1, Kv1.2, and Kv1.6 subtypes, due to its ability to block these channels with high affinity. It is essential for neuroscientists, pharmacologists, and toxicologists engaged in fundamental neurological research, ion channel characterization, and the development of novel therapeutic agents targeting neurological disorders.

Application

• Neuroscience Research: A primary tool for investigating the structure, function, and pharmacology of voltage-gated potassium channels in neuronal signaling and excitability.
• Ion Channel Assays: Used in high-throughput screening (HTS) and patch-clamp electrophysiology to identify and characterize modulators of Kv1 channel activity.
• Toxicology Studies: Serves as a reference standard in venom research and for studying the mechanisms of neurotoxic peptides.
• Drug Discovery: Facilitates target validation and mechanistic studies in programs aimed at developing treatments for epilepsy, multiple sclerosis, and neuropathic pain.
• Biochemical Reagent: Employed in protein-protein interaction studies and for the purification of specific potassium channel subtypes via affinity chromatography.
• Academic & Pharmaceutical R&D: Indispensable for basic research in university laboratories and applied research in biopharmaceutical companies.

Basic Information

Product Name	β-Dendrotoxin
CAS No.	126039-38-1
Molecular Formula	C184H281N55O53S7
Molecular Weight	~4290.9 g/mol
Synonyms	β-Dendrotoxin; Dendrotoxin I; DTX-I; Toxin I (Dendroaspis angusticeps); Dendrotoxin K; Potassium channel toxin α-DTx; ShK-like toxin; UNII-9P10C4S1W5
EINECS	Contact for details

Quality Control

Our β-Dendrotoxin is produced under stringent conditions to ensure the highest standards of purity and biological activity, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, potency, and identity. We adhere to rigorous quality testing protocols to guarantee batch-to-batch consistency and compliance with research-grade standards. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot reconstituted solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Potency (Bioassay)	≥ 98% of stated activity
Water Content (KF)	≤ 5.0%
Endotoxin (LAL)	< 1.0 EU/μg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.