Description

Semaphorin-4D is a high-purity, biologically active protein belonging to the semaphorin family of signaling molecules. This compound is critical for research and development in cell signaling, immunology, and neurobiology, serving as a key ligand for the Plexin-B1 receptor. It is essential for B2B clients in the life sciences sector, including pharmaceutical R&D, biotechnology, and academic research institutions, who require reliable, high-quality reagents for target validation, assay development, and therapeutic discovery programs.

Application

• Biomedical Research: Used as a critical reagent in studies of axon guidance, immune cell regulation, and tumor biology.
• Drug Discovery & Target Validation: Serves as a key protein target or tool compound in screening assays for developing novel therapeutics in oncology and autoimmune diseases.
• Cell Signaling & Pathway Analysis: Essential for investigating the Sema4D-Plexin-B1 signaling axis and its downstream effects in various cell types.
• Diagnostic Assay Development: Utilized in the development of ELISA and other immunoassays to detect Sema4D levels in biological samples for research purposes.
• Reagent Production: Supplied to manufacturers of research kits, antibodies, and other life science research tools.
• Academic & Institutional Research: Provides a standardized, high-quality protein for reproducible experiments in university and government laboratories.

Basic Information

Product Name	Semaphorin-4D
CAS No.	125995-94-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	SEMA4D; CD100; Semaphorin 4D; Semaphorin-D; Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D; FLJ17487; MGC126780; MGC126781
EINECS	Contact for details

Quality Control

Our Semaphorin-4D is produced under stringent quality management systems to ensure batch-to-batch consistency and biological activity. Each lot undergoes comprehensive analytical testing, including purity assessment by SDS-PAGE and HPLC, endotoxin level determination, and functional activity verification in cell-based assays. A detailed Certificate of Analysis (COA) documenting identity, purity, and biological potency is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (SDS-PAGE)	Single band at expected molecular weight
Purity (HPLC)	≥ 95%
Endotoxin Level	< 1.0 EU/μg
Biological Activity (Cell-based assay)	Contact for details
Solubility	Soluble in sterile PBS or cell culture medium

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.