Description

Dibenzo(B,F)Thiepin-10-Ol, 10,11-Dihydro-6-(2-(Dimethylamino)Ethoxy)-, (Z)-2-Butenedioate (1:1) (Salt) is a high-purity, non-racemic pharmaceutical intermediate of significant importance in modern synthetic chemistry. This compound matters for its role as a key chiral building block in the synthesis of complex, biologically active molecules, offering researchers and manufacturers precise control over stereochemistry. It is primarily needed by pharmaceutical R&D teams and fine chemical producers engaged in the development of novel therapeutic agents, particularly within the central nervous system (CNS) and other specialized drug discovery pipelines.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs).
• Drug Discovery & Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities.
• Asymmetric Synthesis: Employed as a sophisticated building block to introduce specific stereocenters in complex organic molecules.
• Reference Standard: Utilized as an analytical standard for quality control and method development in pharmaceutical analysis.
• Process Chemistry Development: Applied in scaling up synthetic routes from laboratory to pilot and commercial production scales.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	Dibenzo(B,F)Thiepin-10-Ol, 10,11-Dihydro-6-(2-(Dimethylamino)Ethoxy)-, (Z)-2-Butenedioate (1:1) (Salt)
CAS No.	125981-99-9
Molecular Formula	C23H25NO5S
Molecular Weight	427.52 g/mol
Synonyms	6-[(2-Dimethylamino)ethoxy]-10,11-dihydrodibenzo[b,f]thiepin-10-ol maleate (1:1); (Z)-2-Butenedioic acid, compd. with 6-[2-(dimethylamino)ethoxy]-10,11-dihydrodibenzo[b,f]thiepin-10-ol (1:1); 10,11-Dihydro-6-[2-(dimethylamino)ethoxy]dibenzo[b,f]thiepin-10-ol maleate; 6-(2-(Dimethylamino)ethoxy)-10,11-dihydrodibenzo[b,f]thiepin-10-ol maleate salt; Dibenzo[b,f]thiepin-10-ol, 10,11-dihydro-6-[2-(dimethylamino)ethoxy]-, (Z)-2-butenedioate (1:1); Maleic acid salt of 6-(2-(dimethylamino)ethoxy)-10,11-dihydrodibenzo[b,f]thiepin-10-ol
EINECS	Contact for details

Quality Control

Our Dibenzo(B,F)Thiepin-10-Ol, 10,11-Dihydro-6-(2-(Dimethylamino)Ethoxy)-, (Z)-2-Butenedioate (1:1) (Salt) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Any individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.