Description

2-[3-(Trifluoromethyl)Phenyl]-3,4-Dihydropyrimidin-4-One is a high-value, fluorinated heterocyclic building block essential for advanced organic synthesis. This compound matters because its unique trifluoromethylphenyl-dihydropyrimidinone scaffold is a critical intermediate for developing novel pharmaceuticals and agrochemicals with enhanced metabolic stability and bioavailability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in kinase inhibitor and antiviral therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group imparts desirable biological activity.
• Material Science Research: Serves as a building block for novel organic electronic materials and liquid crystals due to its rigid, fluorinated structure.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes in fine chemical production.
• Academic & Institutional Research: Used in universities and research institutes for methodological studies in fluorination chemistry and heterocycle synthesis.

Basic Information

Product Name	2-[3-(Trifluoromethyl)Phenyl]-3,4-Dihydropyrimidin-4-One
CAS No.	125903-84-6
Molecular Formula	C₁₁H₇F₃N₂O
Molecular Weight	240.18 g/mol
Synonyms	3,4-Dihydro-2-[3-(trifluoromethyl)phenyl]-4-pyrimidinone; 2-(3-Trifluoromethylphenyl)-3,4-dihydropyrimidin-4-one; 4(1H)-Pyrimidinone, 3,4-dihydro-2-[3-(trifluoromethyl)phenyl]-; 2-(alpha,alpha,α-Trifluoro-m-tolyl)-1,4,5,6-tetrahydropyrimidin-4-one; 2-(3-Trifluoromethylphenyl)-1,4,5,6-tetrahydropyrimidin-4-one; 2-(3-Trifluoromethylphenyl)-1,4-dihydropyrimidin-4-one; TFMP-DHPO; m-Trifluoromethylphenyl dihydropyrimidinone
EINECS	Contact for details

Quality Control

Our 2-[3-(Trifluoromethyl)Phenyl]-3,4-Dihydropyrimidin-4-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures the material meets the high standards required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.