Description

(+)-(R)-Cibenzoline CAS NO 125836-74-0 is the pharmacologically active enantiomer of the class Ia antiarrhythmic agent cibenzoline. This high-purity chiral intermediate is critical for the development and manufacturing of enantiomerically pure cardiovascular drugs, ensuring targeted therapeutic efficacy and minimizing side effects. It is essential for pharmaceutical R&D laboratories and API manufacturers focused on advanced cardiac therapies and chiral synthesis.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: Key chiral building block in the synthesis of (R)-cibenzoline succinate, the therapeutically active form.
• Cardiovascular Drug Research: Used in preclinical and clinical studies for developing new antiarrhythmic agents targeting atrial and ventricular arrhythmias.
• Chiral Synthesis & Resolution Studies: Serves as a reference standard and starting material for method development in asymmetric synthesis and enantiomeric separation.
• Pharmacology & Toxicology Testing: Employed as a standard compound to study the stereospecific pharmacokinetics, metabolism, and safety profile of cibenzoline.
• Pharmaceutical Quality Control: Used as a certified reference material (CRM) for assay and impurity testing of finished drug products.

Basic Information

Product Name	(+)-(R)-Cibenzoline
CAS No.	125836-74-0
Molecular Formula	C18H20N2
Molecular Weight	264.37 g/mol
Synonyms	(R)-Cibenzoline; (R)-(+)-Cibenzoline; (+)-Cibenzoline; (R)-2-(2,2-Diphenylcyclopropyl)-4,5-dihydro-1H-imidazole; (R)-Cifenline; (R)-Cipralan; (R)-Cibenol; (2R)-2-(2,2-Diphenylcyclopropyl)-4,5-dihydro-1H-imidazole
EINECS	Contact for details

Quality Control

Our (+)-(R)-Cibenzoline is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity by HPLC, to ensure compliance with stringent pharmaceutical-grade specifications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤1.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.