Description

(S)-3-Hydroxymandelonitrile is a chiral, non-racemic cyanohydrin derivative of significant interest in fine chemical synthesis. This compound serves as a versatile and valuable chiral building block for the production of complex pharmaceutical intermediates and agrochemicals. It is particularly essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce stereochemistry into their target molecules.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of enantiomerically pure β-blockers, adrenergic agents, and other active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the production of chiral pesticides and herbicides where specific stereochemistry is required for biological activity.
• Asymmetric Synthesis: Employed as a chiral auxiliary or starting material in various asymmetric carbon-carbon bond-forming reactions.
• Fine Chemical Production: Serves as a building block for flavors, fragrances, and other high-value specialty chemicals requiring defined stereochemistry.
• Research & Development: A critical reagent in academic and industrial R&D for exploring new synthetic methodologies and developing novel chiral compounds.

Basic Information

Product Name	(S)-3-Hydroxymandelonitrile
CAS No.	125781-60-4
Molecular Formula	C8H7NO2
Molecular Weight	149.15 g/mol
Synonyms	(S)-3-Hydroxy-2-hydroxy-2-phenylacetonitrile; (S)-2-Hydroxy-2-(3-hydroxyphenyl)acetonitrile; (S)-α-Hydroxy-3-hydroxybenzeneacetonitrile; (S)-3-Hydroxybenzaldehyde cyanohydrin; (S)-Mandelonitrile, 3-hydroxy-; (S)-3-Hydroxyphenylglycolonitrile
EINECS	Contact for details

Quality Control

Our (S)-3-Hydroxymandelonitrile is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure high enantiomeric excess (e.e.) and chemical purity. Certificates of Analysis (COA) detailing specific results for assay, chiral purity, and identified impurities are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere for long-term stability. This compound is moisture-sensitive and should be handled under dry conditions to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (e.e.)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.