Description

Sar1 Protein CAS NO 125524-15-4 is a crucial component of the COPII vesicle coat complex, essential for intracellular protein transport from the endoplasmic reticulum (ER) to the Golgi apparatus. This small GTPase plays a fundamental role in regulating vesicle budding and cargo selection, making it a vital tool for research in cell biology and membrane trafficking. It is primarily utilized by researchers in academic institutions, pharmaceutical R&D, and biotechnology companies studying secretory pathways, protein trafficking disorders, and novel therapeutic targets.

Application

• Fundamental Cell Biology Research: Investigation of COPII vesicle formation, ER-to-Golgi transport mechanisms, and secretory pathway dynamics.
• Protein Trafficking Studies: Used in in vitro reconstitution assays to study cargo selection and vesicle budding from ER membranes.
• Disease Mechanism Research: Exploration of diseases linked to trafficking defects, such as certain forms of cranio-lenticulo-sutural dysplasia and other genetic disorders.
• Drug Discovery Screening: Serves as a target protein in high-throughput screens for compounds that modulate intracellular transport, potentially for treating trafficking-related diseases.
• Biochemical Assay Development: Essential reagent for developing GTPase activity assays and studying protein-protein interactions within the COPII complex.

Basic Information

Product Name	Sar1 Protein
CAS No.	125524-15-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	SAR1A; SAR1 gene homolog A; GTP-binding protein SAR1a; Secretion-associated Ras superfamily 1A; COPII-associated small GTPase; SAR1; SAR1 protein homolog A; hSar1p
EINECS	Contact for details

Quality Control

Our Sar1 Protein is produced under stringent conditions to ensure high purity and biological activity, suitable for sensitive research applications. Each batch undergoes rigorous quality testing, including analysis for purity, identity, and functional activity. A comprehensive Certificate of Analysis (COA) detailing specifications such as concentration, purity (by SDS-PAGE), endotoxin levels, and GTPase activity is provided with every shipment to guarantee batch-to-batch consistency and reliability for your research.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at ≤ -20°C in small aliquots to avoid repeated freeze-thaw cycles. Use appropriate aseptic techniques when handling to prevent contamination. Always follow the specific storage instructions provided on the product label and accompanying documentation.

Specification

Item	Specification
Appearance	Clear, colorless solution
Purity (SDS-PAGE)	≥ 90%
Concentration	Provided on COA
Buffer Composition	Provided on COA
Endotoxin Level	< 1.0 EU/µg
Biological Activity (GTPase)	Confirmed by functional assay
Storage Buffer	Tris-based buffer with stabilizing agents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.