Description

Dehydronifedipine-D-6 is a deuterium-labeled isotopologue of a key nifedipine derivative, serving as a critical internal standard for precise analytical quantification. This high-purity reference material is essential for ensuring accuracy and reliability in sensitive mass spectrometry-based analyses. It is primarily required by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical testing facilities engaged in method development, pharmacokinetic studies, and impurity profiling.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the accurate quantification of nifedipine and its metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmaceutical R&D: Supports method development and validation in drug metabolism and pharmacokinetics (DMPK) studies for calcium channel blocker research.
• Bioanalytical Assays: Enhances the precision and reliability of high-performance liquid chromatography (HPLC) and tandem mass spectrometry assays in clinical and preclinical trials.
• Metabolite Identification: Aids in the identification and structural elucidation of drug metabolites using isotopic patterning.
• Quality Control & Impurity Profiling: Employed in the analysis of active pharmaceutical ingredients (APIs) to monitor process-related impurities and ensure batch-to-batch consistency.
• Forensic & Doping Analysis: Utilized in specialized testing laboratories for the confirmatory analysis of specific pharmaceutical compounds.

Basic Information

Product Name	Dehydronifedipine-D-6
CAS No.	125464-52-0
Molecular Formula	C17H12D6N2O6
Molecular Weight	348.37 g/mol
Synonyms	Dehydronifedipine-d6; 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid Dimethyl Ester-d6 (Dehydro); 2,6-Dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic Acid Dimethyl Ester-d6 (Dehydro); Deuterated Dehydronifedipine; Nifedipine Impurity D-d6; Nifedipine Related Compound D-d6; [2H6]-Dehydronifedipine
EINECS	Contact for details

Quality Control

Our Dehydronifedipine-D-6 is manufactured under strict quality control protocols to ensure the highest isotopic and chemical purity required for analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for assay, isotopic enrichment, and related substance analysis. We adhere to relevant industry standards for reference materials to guarantee reliable and reproducible performance in your critical assays.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the material should be handled in a low-humidity environment and the container kept sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.