Description

(Tyr15)-Fibrinopeptide B CAS NO 125455-56-3 is a synthetic peptide fragment derived from the fibrinogen beta chain, specifically modified at the tyrosine-15 position. This high-purity biochemical is a critical research tool for studying the mechanisms of blood coagulation, fibrinolysis, and related enzymatic processes. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic manufacturers focused on cardiovascular disease, thrombosis research, and the development of novel hemostatic agents.

Application

• Biochemical Research: A key substrate and reference standard for investigating thrombin activity, fibrin formation kinetics, and the detailed molecular interactions of the coagulation cascade.
• Pharmaceutical Development: Used in the screening and validation of new anticoagulant and antithrombotic drug candidates targeting specific cleavage sites in fibrinogen.
• Diagnostic Assay Calibration: Serves as a precise calibrator and control material in clinical diagnostic kits for measuring fibrinopeptide B levels, a marker for in vivo thrombin generation.
• Enzyme Kinetics Studies: Employed to determine kinetic parameters (Km, Vmax) and inhibition constants (Ki) for thrombin and other serine proteases.
• Mass Spectrometry Standard: Acts as a high-purity internal standard in proteomics and biomarker discovery research related to cardiovascular pathologies.

Basic Information

Product Name	(Tyr15)-Fibrinopeptide B
CAS No.	125455-56-3
Molecular Formula	C92H124N24O29S2
Molecular Weight	2062.2 g/mol
Synonyms	Fibrinopeptide B (Tyr15); Human Fibrinopeptide B (Tyr15); FpB (Tyr15); H-Gly-Val-Asn-Asp-Asn-Glu-Glu-Gly-Phe-Phe-Ser-Ala-Arg-Tyr-OH; Bβ 1-15 (Tyr15); Fibrinogen beta chain peptide (1-15), Tyr15 variant; Thrombin substrate peptide (Fibrinopeptide B-based).
EINECS	Contact for details

Quality Control

Our (Tyr15)-Fibrinopeptide B is manufactured under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry for identity confirmation. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, documenting purity, peptide content, and solvent residues to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Solubility	Soluble in water, dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.