Description

Hemoglobin α-Chain Fragments (123-136) CAS NO 125379-00-2 is a defined synthetic peptide sequence corresponding to residues 123-136 of the human hemoglobin alpha chain. This high-purity peptide fragment is a critical research tool for immunological studies, epitope mapping, and the development of diagnostic assays. It is primarily utilized by biotechnology, pharmaceutical, and academic research institutions focused on hematology, autoimmune disorders, and vaccine development.

Application

• Immunological Research: Used as a specific antigen for studying antibody responses and T-cell reactivity in hemoglobin-related disorders.
• Epitope Mapping: Essential for identifying and characterizing specific binding sites (epitopes) on the hemoglobin molecule for monoclonal antibody development.
• Diagnostic Assay Development: Serves as a key component in the development of ELISA and other immunoassays for detecting specific antibodies.
• Biomarker Studies: Employed in research investigating hemoglobin fragments as potential biomarkers for various pathological conditions.
• Peptide-Based Vaccine Research: Investigated as a candidate peptide for therapeutic vaccines targeting hemoglobinopathies or related autoimmune conditions.
• Quality Control Standard: Acts as a reference standard in the quality control of related biological products and diagnostic kits.

Basic Information

Product Name	Hemoglobin α-Chain Fragments (123-136)
CAS No.	125379-00-2
Molecular Formula	C68H111N21O22
Molecular Weight	1550.75 g/mol
Synonyms	Hemoglobin alpha chain (123-136); HBA(123-136); HbA α-chain fragment 123-136; α-hemoglobin fragment 123-136; Synthetic hemoglobin peptide; Hemoglobin α-subunit residues 123-136; L-Val-Val-Ala-Gly-Val-Ala-Asn-Ala-Leu-Ala-His-Lys-Tyr-His (V V A G V A N A L A H K Y H)
EINECS	Contact for details

Quality Control

Our Hemoglobin α-Chain Fragments (123-136) is manufactured under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including HPLC for purity and MS for identity confirmation, to meet the exacting standards required for research and development. A Certificate of Analysis (COA) detailing purity, peptide content, and analytical data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Composition	Conforms to theoretical values (±10%)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.