Description

n-Acetyl-L-Proline Ethyl Ester is a high-purity, protected amino acid derivative widely used in advanced organic synthesis. This compound serves as a critical chiral building block for the preparation of complex peptides and peptidomimetics, offering excellent control over stereochemistry. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries engaged in drug discovery and development.

Application

• Pharmaceutical Intermediates: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to introduce proline derivatives with an acetyl-protected amine.
• Bioconjugation & Probe Development: Serves as a building block for creating labeled peptides and molecular probes for biochemical research.
• Catalyst & Ligand Preparation: Employed in the development of chiral catalysts and ligands for asymmetric synthesis.
• Cosmetic Peptides: A potential intermediate in the manufacture of certain bioactive peptides for cosmetic applications.
• Academic & Industrial R&D: A valuable reagent for chemical research in medicinal chemistry and organic synthesis laboratories.

Basic Information

Product Name	n-Acetyl-L-Proline Ethyl Ester
CAS No.	125347-82-2
Molecular Formula	C9H15NO3
Molecular Weight	185.22 g/mol
Synonyms	L-Proline, N-acetyl-, ethyl ester; Ethyl N-acetyl-L-prolinate; N-Acetyl-L-proline ethyl ester; N-Acetylproline ethyl ester; Ac-L-Pro-OEt; (S)-1-(Ethoxycarbonyl)-2-pyrrolidinecarboxylic acid, N-acetyl-; Ethyl (2S)-1-acetylpyrrolidine-2-carboxylate; N-Acetyl-L-proline ethylester
EINECS	Contact for details

Quality Control

Our n-Acetyl-L-Proline Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis, to ensure it meets the high standards required for research and production. Certificates of Analysis (COA) detailing identity, purity, and specific impurities are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.