Description

L-2,2,2-Trifluoro-1-(Methyl)Ethylamine CAS NO 125278-10-6 is a specialized chiral amine building block featuring a trifluoromethyl group, which imparts unique physicochemical properties. This compound is valued for its role as a key intermediate in the synthesis of advanced pharmaceuticals and agrochemicals, where the introduction of fluorine atoms can dramatically enhance metabolic stability and bioavailability. It is primarily sought by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex, high-value molecules.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly in protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves efficacy and environmental profile.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Fluorinated Amino Acid Analogue: Employed in peptide and peptidomimetic research to study structure-activity relationships and enhance peptide stability.
• Advanced Material Research: A building block for fluorinated polymers and specialty chemicals with tailored surface properties.
• Diagnostic Reagent Development: Potential use in creating fluorinated probes and markers for imaging and bioanalytical applications.

Basic Information

Product Name	L-2,2,2-Trifluoro-1-(Methyl)Ethylamine
CAS No.	125278-10-6
Molecular Formula	C4H8F3N
Molecular Weight	127.11 g/mol
Synonyms	(S)-1,1,1-Trifluoropropan-2-amine; (S)-2-Amino-1,1,1-trifluoropropane; L-α-Trifluoromethyl ethylamine; (S)-α-(Trifluoromethyl)ethylamine; (S)-1-Amino-2,2,2-trifluoropropane; (S)-1,1,1-Trifluoro-2-propylamine; (S)-2,2,2-Trifluoro-1-methylethylamine; (S)-TFPA
EINECS	Contact for details

Quality Control

Our L-2,2,2-Trifluoro-1-(Methyl)Ethylamine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with each shipment. We support compliance with cGMP, ISO, and REACH regulations as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its highly volatile and fluoride/strong alkali nature, ensure containers are kept tightly sealed and away from incompatible materials. For long-term storage, consider using inert atmosphere headspace.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC/HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.