Description

Marcks Protein (151-175) Bovine is a defined peptide fragment derived from the myristoylated alanine-rich C kinase substrate (MARCKS) protein, specifically corresponding to amino acid residues 151-175 of the bovine sequence. This synthetic peptide is a critical research tool for studying protein kinase C (PKC) signaling pathways, membrane-cytoskeleton interactions, and cellular processes such as secretion and motility. It is primarily utilized by researchers and developers in the fields of biochemical research, neuroscience, and pharmaceutical development for investigating molecular mechanisms and validating therapeutic targets.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic assays to study Protein Kinase C (PKC) activity and specificity.
• Neuroscience Studies: Employed in research on synaptic plasticity, neurotransmitter release, and neuronal development where MARCKS protein plays a regulatory role.
• Cell Signaling Pathway Analysis: Serves as a key reagent to investigate signal transduction mechanisms involving calcium/calmodulin and actin cytoskeleton dynamics.
• Drug Discovery & Validation: Acts as a target or tool compound in high-throughput screening (HTS) campaigns and mechanism-of-action studies for potential neuroactive or anticancer agents.
• Antibody Production & Epitope Mapping: Used as an immunogen or antigen for generating and characterizing specific antibodies against the MARCKS protein domain.
• In vitro Diagnostic (IVD) Development: Potential use as a calibrated component in assay kits designed to measure PKC activity or related biomarkers.

Basic Information

Product Name	Marcks Protein (151-175) Bovine
CAS No.	125267-21-2
Molecular Formula	C129H209N39O38
Molecular Weight	2846.3 g/mol (theoretical)
Synonyms	MARCKS (151-175); MARCKS Peptide (151-175), bovine; PKC Substrate Peptide (MARCKS); Myristoylated Alanine-Rich C Kinase Substrate fragment 151-175; MARCKS Effector Domain (ED) peptide; [Lys155,156,163,164]-MARCKS (151-175); MANS peptide analog; MRP (151-175)
EINECS	Contact for details

Quality Control

Every batch of Marcks Protein (151-175) Bovine is manufactured and analyzed under strict quality protocols. Our products undergo rigorous quality testing to ensure compliance with industry standards for research-grade peptides. Certificates of Analysis (COA) are available upon request, providing detailed data on purity, identity, and composition.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Amino Acid Composition	Conforms to theoretical sequence
Peptide Content	≥ 80% (by weight)
Solubility	Soluble in water or aqueous buffer
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.