Description

Alprazolam-D5 is a stable isotope-labeled internal standard, specifically a deuterated analog of the pharmaceutical compound Alprazolam. This high-purity reference material is critical for ensuring accuracy and reliability in quantitative analytical methods. It is primarily utilized by research institutions, pharmaceutical developers, and analytical laboratories engaged in pharmacokinetic studies, drug metabolism research, and forensic analysis.

Application

• Quantitative Mass Spectrometry: Serves as an essential internal standard for the precise quantification of Alprazolam in biological matrices (e.g., plasma, serum, urine) using LC-MS/MS and GC-MS techniques.
• Pharmacokinetic & Bioavailability Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and preclinical research.
• Forensic & Clinical Toxicology: Used as a reference standard in the confirmation and accurate measurement of Alprazolam levels for medico-legal and diagnostic purposes.
• Pharmaceutical R&D and Quality Control: Supports method development and validation for the analysis of active pharmaceutical ingredients (APIs) and finished drug products.
• Metabolite Identification: Aids in the structural elucidation and quantification of Alprazolam metabolites in complex samples.
• Regulatory Compliance Testing: Facilitates testing that adheres to guidelines from agencies like the FDA and EMA, ensuring data integrity for regulatory submissions.

Basic Information

Product Name	Alprazolam-D5
CAS No.	125229-61-0
Molecular Formula	C17H8D5ClN4
Molecular Weight	313.78 g/mol
Synonyms	8-Chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-d5; Alprazolam (phenyl-d5); Alprazolam-d5 (Major); Deuterated Alprazolam; Alprazolam Internal Standard; Xanax-d5; [2H5]-Alprazolam
EINECS	Contact for details

Quality Control

Our Alprazolam-D5 is manufactured under strict quality systems to ensure the highest standards of isotopic purity and chemical identity required for analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results from advanced spectroscopic and chromatographic tests, including NMR, HPLC, and MS. We provide traceable documentation to support GLP/GMP compliance for research and regulatory purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuteration)	≥ 98 atom % D
Chemical Purity	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.